PHCbi
PHC株式会社 バイオメディカ機器 Live Cell Metabolic Analyzer (LiCellMo)

Live Cell Metabolic Analyzer

JP|EN

Continuous, sampling-free measurement of glucose and lactate in culture medium. Visualize real-time changes in cell metabolism

Cells are constantly growing and differentiating, and these processes are known to be closely linked to metabolism.
In the field of cancer immunology, stem cell research, and the development of manufacturing processes for cell-based formulations,
understanding the metabolic state of cells is a factor of ever-growing importance in the analysis of cell activation and disease.
Continuous analysis of cell metabolism offers the ability to visualize the state of cells in real time, creating opportunities for unprecedented new discoveries in cell metabolism.
The PHCbi Live cell metabolic analyzer will open new doors to those discoveries.

This product is for research use only.
Do not use for medical purposes.
  • Cancer
    Research
  • Immunology
    Research
  • Stem Cell
    Research
  • Metabolism
    Research
  • Process
    Development

Visualization of continuous changes in cell metabolism Continuous measurement of glucose and lactate using in-line sensors

Glycolysis is one of the main pathways of cellular energy metabolism and involves cellular uptake of glucose and production of lactate. In conventional analysis of cellular metabolism, changes in the metabolic state of cells were determined from point data for glucose and lactate concentrations based on a few samplings per day. Using unique high-precision in-line sensors, the LiCellMoTM live cell metabolic analyzer from PHCbi can perform real-time, continuous measurement of glucose taken into cells for growth and differentiation in culture medium and lactate produced during this process. And because cell activity can be measured without sampling the medium, the cells can also be used for separate evaluation after assay.

Measurements can be carried out in the usual culture environment.
Consumables used for routine culture can be used without modification

The detector is inserted in the CO2 incubator before use. The sensor module and plate adapter can be attached to a standard 24-well plate. Then, once the plate is placed in the detector, real-time measurements can be checked easily using the touch-panel controller. This simple configuration is suitable for any laboratory space. Commercially available consumables can be used for cell culture, and plate adapters compatible with five different commercial 24-well plates are available separately. (Please purchase the plate adapter compatible with your well plate separately.)

Measure glycolysis directly from changes in glucose and lactate concentrations.
Evaluate glycolytic changes directly.

Changes in the glycolytic pathway can be evaluated directly by measuring the culture medium concentrations of glucose taken up by cells and the lactate produced. The state of cellular metabolism can be visualized as the rate of metabolic change using the consumption rate and production rate based on concentration values. Monitoring the efficiency of conversion from glucose to lactate makes it possible to evaluate not only glycolysis, but also changes in the balance with other cellular metabolic processes, such as oxidative phosphorylation.

PHC’s Live Cell Metabolic Analyzer “LiCellMo™”
Wins the Prestigious International Scientific and Technology Award,
the 2025 R&D 100 Award

Brochure Download

Application Note / Library / Case Studies

Application Note
Library
Case Studies

References（items）

  • Ishihara et al. The PKM2 activator TEPP-46 suppresses cellular senescence in hydrogen peroxide-induced proximal tubular cells and kidney fibrosis in CD-1db/db mice. J Diabetes Invetig vol. 16,4 (2025): 598-607.
    PubMed: 39840670
  • Miki et al. Live-cell metabolic analyzer protocol for measuring glucose and lactate metabolic changes in human cells. STAR Protoc 6:103518.
    PubMed: 39799573
  • Yamamoto et al. Suppressive effect of the anesthetic propofol on the T cell function and T cell-dependent immune responses. Sci Rep 14:19337 (2024).
    PubMed: 39164311
  • Lactylated Apolipoprotein C-II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis.Adv Sci 11 11(38):e2406333 (2024).
    PubMed: 38981044
  • Intracellular domain uses a 4-1BB-like metabolic pathway driven by cholesterol biosynthesis.J Immunother Cancer 14(3) (2026).
    PubMed: 41813235

Product Specifications

External view and dimensions (unit: mm)

Specifications

Product Summary Items monitored Glucose, lactate (simultaneous continuous measurement of both items)
Main device components Controller, Detector, Plate adapter (optional product)
Main consumables Sensor module (single use)
Compatible plates 24-well plate
*Compatible with 5 commercial products
Monitoring duration Maximum 10 days
Measurement range Glucose: 1−27 mM
(0.18−4.86 g/L)
Lactate: 1.5−15 mM
(0.14−1.35 g/L)
Controller External dimensions Width 371 mm × Depth 200 mm × Height 295 mm
Weight 2.5 kg (excluding accessories)
Screen 15.6-inch-wide touch panel display
Extendability Wired connectivity for up to 4 detectors
Detector External dimensions Width 162 mm × Depth 290 mm × Height 118 mm
Weight 4.7 kg
Installation Inside CO2 incubator
Number of units installable
in PHC incubators*
MCO-50 series MCO-170 series,
MCO-171AICD series		 MCO-230 series
Max. 1 unit Max. 4 units
(2 units × 2 shelves)		 Max. 4 units
(2 units × 2 shelves)

*If installing two detectors on one shelf, use a dedicated reinforced tray (MCO-170RT-PW / MCO-230RT-PW).